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Abstract #0955

Extra-Cranial Measurements of Amide Proton Transfer using Exchange-Modulated Point-Resolved Spectroscopy (EXPRESS)

Simon Walker-Samuel1, Peter Johnson2, Barbara Pedley2, Mark F. Lythgoe*1, Xavier Golay*3

1UCL Centre for Advanced Biomedical Imaging, Department of Medicine & Institute of Child Health, University College London, London, United Kingdom; 2Institute of Cancer, University College London, United Kingdom; 3Institute of Neurology, University College London, United Kingdom

Chemical exchange saturation transfer (CEST) imaging has been used experimentally in a broad range of applications. However, full quantification of CEST effects in vivo using standard imaging sequences is time consuming as a large number of saturation frequency offsets are required to define a z-spectrum. Furthermore, outside the brain, the presence of fat can confound the interpretation of z-spectra. A novel acquisition and post-processing technique is presented in this study, named exchange-modulated point resolved spectroscopy (EXPRESS), which aims to address these limitations and enables spatially localised, high signal-to-noise measurements of CEST effects in vivo.