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Abstract #0956

Promoted Growth of Brain Tumor with Severe Hemorrhage by the Transplantation of Neural Progenitor Cells Facilitated by SDF-1

Nai-Wei Yao1,2, Chiao-Chi V Chen1,3, Chen Chang1,3

1Functional & Micro-magnetic Resonance Imaging Center, Academic Sinica, Taipei, Taiwan; 2Institute of Zoology, National Taiwan University, Taipei, Taiwan; 3Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

The targeted migration of neural progenitor cells (NPCs) towards brain injuries is mediated by chemokines, such as stromal cellVderived factor-1 (SDF-1). It is thus hypothesize that the transplantation of NPCs with an elevated SDF-1 gradient leads to stronger migration to the tumor site, which may cause a different growing pattern and morphology of the tumor. The present study demonstrates that combinative treatment of NPC with SDF-1 rendered tumors exhibit rapid growth with sever hemorrhage. The finding identified an important role of NPCs facilitated by SDF-1 in tumor expansion.