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Abstract #0957

High Resolution Magnetic Resonance Elastography of Orthotopic Murine Glioma In Vivo

Yann Jamin1, Jessica K. R. Boult1, Jeffrey C. Bamber1, Ralph Sinkus2, Simon P. Robinson1

1CRUK & EPSRC Cancer Imaging Centre, The Institute of Cancer Research & Royal Marsden NHS Trust, Sutton, United Kingdom; 2INSERM U773, CRB3, Centre de Recherches Biomdicales Bichat-Beaujon, Paris, France

In this proof-of-principle study, we demonstrate that magnetic resonance elastography (MRE) affords noninvasive measurements of the visco-elastic properties of orthotopic murine gliomas. We have specifically assessed the visco-elastic properties of orthotopically propagated RG2 gliomas in mouse brain, which are a faithful representation of the most common primary brain tumour, astrocytoma. MRE revealed that RG2 gliomas were softer and less viscous than the surrounding brain tissue, which is consistent with the described appearance of the RG2 glioma model and astrocytomas in the clinic.