Abstract #1019

Analysis of the Normalized Radial Length Reveals Differences in Morphology Between Hormone Receptor Positive & Negative Breast Lesions Imaged with DCE-MRI

Fang Liu^1,2, Anat Kornecki³, Olga Shmuilovich³, Yves Bureau^1,2, Neil Gelman^1,2

¹Imaging Division, Lawson Health Research Institute, London, Ontario, Canada; ²Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada; ³Department of Diagnostic Imaging, St. Joseph's Health Center, London, Ontario, Canada

This abstract presents an investigation of quantitative morphological features in hormone receptor positive and negative tumors obtained from dynamic contrast enhanced magnetic resonance images. In order to characterize the degree of tumor surface irregularity, quantitative morphological measures which describe the distribution of normalized radial lengths of each tumor were extracted and compared between breast tumors with different estrogen receptor (ER) and progesterone receptor (PR) status. Our results suggest that ER-/PR- tumors may have larger surface irregularities than ER+/PR+ tumors.