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Abstract #1019

Analysis of the Normalized Radial Length Reveals Differences in Morphology Between Hormone Receptor Positive & Negative Breast Lesions Imaged with DCE-MRI

Fang Liu1,2, Anat Kornecki3, Olga Shmuilovich3, Yves Bureau1,2, Neil Gelman1,2

1Imaging Division, Lawson Health Research Institute, London, Ontario, Canada; 2Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada; 3Department of Diagnostic Imaging, St. Joseph's Health Center, London, Ontario, Canada

This abstract presents an investigation of quantitative morphological features in hormone receptor positive and negative tumors obtained from dynamic contrast enhanced magnetic resonance images. In order to characterize the degree of tumor surface irregularity, quantitative morphological measures which describe the distribution of normalized radial lengths of each tumor were extracted and compared between breast tumors with different estrogen receptor (ER) and progesterone receptor (PR) status. Our results suggest that ER-/PR- tumors may have larger surface irregularities than ER+/PR+ tumors.