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Abstract #1020

Dynamic Contrast-Enhanced MRI in Triple Negative Breast Carcinomas: is there a Distinct Imaging Phenotype?

Sonia P. Li1, N. Jane Taylor2, J. James Stirling2, Mei-Lin W. Ah-See1, Mark J. Beresford1, David J. Collins3, James A. d'Arcy3, Andreas Makris1, Anwar R. Padhani2

1Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, United Kingdom; 2Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, United Kingdom; 3CRUK-EPSRC Cancer Imaging Centre, Institute of Cancer Research & Royal Marsden Hospital, Sutton, Surrey SM2 5PT, United Kingdom

Triple negative breast carcinomas (TNBC) are oestrogen (ER), progesterone (PR) and HER2 receptor negative, with evidence suggesting that they are a distinct biological entity with aggressive features and limited treatment options. DCE-MRI characteristics of these tumours were compared to a more favourable prognostic group, ER PR breast cancers. The increased cellularity and scant stromal content of TNBC was reflected by lower values for ve, a parameter describing the extravascular extracellular space. Increased kep values consistent with the rapid return of contrast into the vasculature, suggest a higher capillary permeability in triple negative breast cancers.