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Abstract #1027

Optimisation of B-Values for Diffusion-Weighted Imaging of the Breast

Marco Borri1, Maria a Schmidt1, Matthew Blackledge1, Erica Scurr1, Elizabeth O'Flynn1, David Collins1, Matthew Orton1, Veronica Morgan1, Nandita de Souza1, Martin O. Leach1

1Cancer Research UK and EPSRC Cancer Imaging Centre, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton, United Kingdom

Breast-DWI has been used in cancer diagnostic and monitoring of treatment response. Accurate calculation of Apparent Diffusion Coefficient(ADC) is essential and depends on the choice of b-values. In this work we utilise ADC data from large breast lesions to calculate optimal b-values, and compare protocols using different numbers of b-values. The calculated separation (1150s/mm2) is larger than the range of b-values used in many published clinical studies. Our data did not show significant advantage in the use of 2 b-values only, while a larger number of b-values could minimize artifacts and ensure correct sampling for a larger range of ADC-values.