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Abstract #1028

Improved Diagnostic Accuracy of Breast MRI through Combined Apparent Diffusion Coefficients & Dynamic Contrast-Enhanced Kinetics

Savannah C. Partridge1, Habib Rahbar1, Revathi Murthy2, Xiaoyu Chai3, Brenda Kurland3, Wendy DeMartini1, Constance Lehman1

1Radiology, University of Washington, Seattle, WA, United States; 2Bioengineering, University of Washington, Seattle, WA, United States; 3Clinical Statistics, Fred Hutchinson Cancer Research Center, Seattle, WA, United States

In this study, we investigated the correlation between ADC and DCE kinetic characteristics of 100 breast lesions and evaluated the relative diagnostic value of each quantitative measure alone and in combination. We found that lower ADC values (higher cellularity) were associated with more suspicious kinetics and that both DWI and DCE parameters significantly discriminated between benign and malignant lesions. A multivariate model incorporating ADC and worst kinetic curve type provided the greatest discriminative ability, suggesting that DWI provides distinct and complementary information to DCE for characterizing breast lesions.