Stefan Alexandru Carp1, Christy M. Wanyo1, David Alan Boas1
Measurement of breast tissue response to external stimulation has the potential to unveil additional dynamic biomarkers of disease states. Recently tumor contrast generated by breathing-gas induced vascular changes has been demonstrated using both BOLD contrast and MRI-guided near infrared diffuse optical tomography. At the same time, temporally resolved hemodynamic changes due to external compression are being investigated as breast cancer biomarkers. We have developed an integrated MRI-optical breast compression platform to enable simultaneous dynamic optical and MRI acquisition of the post-compression dynamics. We describe the instrumentation development and report initial dynamic MRI results from healthy compressed breast tissue.