Abstract #1044

The Time-to-Peak Hot Spot Volume as an Indicator of Lesion Malignancy in Breast Dynamic Contrast Enhanced-MRI

Fang Liu^1,2, Anat Kornecki³, Olga Shmuilovich³, Neil Gelman^1,2

¹Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada; ²Imaging Division, Lawson Health Research Institute, London, Ontario, Canada; ³Department of Diagnostic Imaging, St. Joseph's Health Center, London, Ontario, Canada

Various empirical parameters have been employed for quantitative analysis of signal enhancement curves in dynamic contrast enhanced-MRI. Among them, the time-to-peak has shown promise as a diagnostic indicator. In this study, a measure to be referred to as the time-to-peak hot spot volume was analyzed and optimized for differentiating benign versus malignant breast lesion. An investigation of the relation of hot spot volume to the lesion volume was also investigated. Our results suggest that quantitative analysis of the time-to-peak hot spot volume can be optimized for diagnostic performance providing indicators for differentiating benign versus malignant breast lesions.