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Abstract #1065

Reproducibility of the Apparent Diffusion Coefficient in Liver Metastases of Colorectal Cancer & Assessment of Correlation with FDG-PET.

Linda Heijmen1, Arend Heerschap2, Edwin ter Voert2, Wim Oyen3, Hans de Wilt4, Cees Punt, Lioe-Fee de Geus- Oei3, Hanneke van Laarhoven1

1Medical Oncology, Radboud University Nijmegen, Medical Centre, Nijmegen, Gelderland, Netherlands; 2Radiology, Radboud University Nijmegen, Medical Centre, Nijmegen, Netherlands; 3Nuclear Medicine, Radboud University Nijmegen, Medical Centre; 4Surgery, Radboud University Nijmegen, Medical Centre

Diffusion weighted imaging (DWI) is a technique that shows potential for early response monitoring of cancer therapies. For the assessment of the value of DWI for early response monitoring in metastasized colorectal cancer knowledge of reproducibility study is crucial. In this study, the reproducibility of DWI and FDG-PET was investigated in liver metastases of colorectal cancer. A good reproducibility (coefficient of reproducibility 0.27) for the mean ADC was obtained. The distribution of ADC in a histogram also showed good reproducibility. A trend towards a negative correlation with mean standardized uptake values of FDG was found.