Renu M. Stephen1, Denise J. Roe,12, Abhinav K. Jha3, Haiyan Cui1, Georgette Frey1, Scott Squire4, Ted P. Trouard,45, Jean P. Galons4, Jeff J. Rodriquez6, Mathew A. Kupinski3,4, Eric Outwater7, Robert J. Gillies7, Alison T. Stopeck1
1Arizona Cancer Center, University of Arizona, Tucson, AZ, United States; 2Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson; 3College of Optical Sciences, University of Arizona, Tucson; 4Department of Radiology, University of Arizona, Tucson; 5Biomedical Engineering, University of Arizona, Tucson; 6Electrical & Computer Engineering, University of Arizona, Tucson; 7H.Lee Moffitt Cancer Center & Research Institute, Tampa, FL
The purpose of this study was to optimize a protocol for obtaining reproducible results for DW-MRI of liver metastases. ADC values measured in metastatic liver lesion from breast cancer are affected by both imaging and tumor parameters. We investigated choice of b values, lesion segmentation, baseline ADC, lesion size, and the number of prior treatments as possible modulators of chemotherapy response. Our results indicate that prior treatment history and low pre-treatment ADC values analyzed using an appropriate choice of b value aid in predicting tumor response.