Anita Banerji1,2, Josephine H. Naish1,2, Giovanni A. Buonaccorsi1, Geoff J. M. Parker1,2
1Imaging Sciences & Biomedical Engineering, Manchester University, Manchester, United Kingdom; 2Biomedical Imaging Institute, Manchester, United Kingdom
Estimation of tracer kinetic model parameters from DCE-MRI data typically relies on the use of an optimisation algorithm for fitting the model to time course data and for estimating T1 from variable flip angle images. We compare the precision and accuracy of model parameters estimated using different frequently employed algorithms and demonstrate that choice of algorithm has little influence on Ktrans. We also show that estimating T1 by linearising the pulse sequence equation does not lead to a loss of precision or accuracy of the estimated Ktrans values.