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Abstract #1073

Precision & Accuracy of Ktrans Estimated by Fitting the Extended Kety Model Parameters to DCE-MRI Time Course Data is Unaffected by the Choice of Optimisation Algorithm or Estimation of T1 using Linearisation

Anita Banerji1,2, Josephine H. Naish1,2, Giovanni A. Buonaccorsi1, Geoff J. M. Parker1,2

1Imaging Sciences & Biomedical Engineering, Manchester University, Manchester, United Kingdom; 2Biomedical Imaging Institute, Manchester, United Kingdom

Estimation of tracer kinetic model parameters from DCE-MRI data typically relies on the use of an optimisation algorithm for fitting the model to time course data and for estimating T1 from variable flip angle images. We compare the precision and accuracy of model parameters estimated using different frequently employed algorithms and demonstrate that choice of algorithm has little influence on Ktrans. We also show that estimating T1 by linearising the pulse sequence equation does not lead to a loss of precision or accuracy of the estimated Ktrans values.