Meeting Banner
Abstract #1074

Anti-Angiogenic Therapy Follow-Up in a Mouse Tumor Model by a Novel 3D Radial Multi-Gradient Echo DCE MRI Technique with Individual AIF Measurement

Nadine El Tannir El Tayara1,2, Nidhal Ben Achour1,2, Christine Walczak1,2, Fariba Nemati3, Joel Mispelter1,2, Didier Decaudin3, Julien Vautier1,2, Andreas Volk1,2

1Research Center, Institut Curie, Orsay, France; 2U759 INSERM, Orsay, France; 3Translational Research Department, Institut Curie, Paris, France

The purpose of this work was to evaluate a new quantitative DCE-MRI technique combining 3D tumor imaging with interleaved high time resolution 2D heart imaging (AIF) in a context of treatment follow-up. We investigated its ability to assess early change of microvascular parameters under anti-angiogenic therapy (Sunitinib) and showed a histograms Ktrans distribution shift towards lower values at day 4 after treatment initiation. Significant decrease in Ktrans median and mode values was observed, as well as tumor growth inhibition over the 11 days treatment period. Results were compatible with a predictive value of these Ktrans parameters for anti-angiogenic treatment response.