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Abstract #1133

USPIO-Enhanced δR2* MR-Relaxometry for In-Vivo Monitoring of Fracture Healing

Thorsten Persigehl1,2, Britta Wiesktter3, Stefanie Remmele4, Hannah Tiggemann3, Janine Ring1, Jochen Keupp4, Walter Heindel1, Christoph Bremer1, Richard Stange3, Volker Vieth1

1Department of Clinical Radiology, University Hospital Muenster, Mnster, NRW, Germany; 2Department of Radiology, Columbia University Medical Center, New York, NY, United States; 3Department of Trauma, Hand & Reconstructive Surgery, University Hospital Muenster, Mnster, NRW, Germany; 4Philips Research Hamburg, Hamburg, HH, Germany

Angiogenesis is an essential progress in bone fracture healing. The aim of this study was to evaluate USPIO-enhanced susceptibly-corrected ∆R2* MR-relaxometry in a bone fracture rat model. USPIO-enhanced ∆R2* MR-relaxometry was performed on day 0, 7, 14, 21, and 28 after surgery and confirmed by histological microvessel density analysis. Thus, we concluded that ∆R2* MR-relaxometry allows an in-vivo monitoring of angiogenic changes in fracture healing and may facilitate experimental studies in bone repair, investigation of its underlying mechanisms, and possible novel molecular therapies.