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Abstract #1134

Perfusion Measurements of Subchondral Bone in Patellofemoral Joint of Rats with Experimental OA Model

Ping-Huei Tsai1, Cheng-Chieh Cheng1, Ming-Huang Lin2, Chien-Yuan Lin2, Herng-Sheng Lee3, Hsiao-Wen Chung1, Guo-Shu Huang4

1Graduate Institute of Biomedical Electronics & Bioinformatics, National Taiwan University, Taipei, Taiwan; 2Functional & Micro-Magnetic Resonance Imaging Center, Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan; 3Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; 4Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

Osteoarthritis (OA) is a disease related to the degeneration of knee cartilage and pathological changes of subchondral bone, which can lead to inflammation and pain. Several studies have demonstrated the importance of early detection of OA using quantitative measurements of MR T2 values of knee cartilage. In addition, perfusion change of bone would result in bone remodeling and cartilage degeneration. Therefore, the purpose of this study is using DCE-MRI to measure bone perfusion of rat patellofemoral joint with experimental OA. Our preliminary finding indicated the feasibility of using DCE-MRI to investigate bone perfusion during the progression of OA, which may contribute to early detection of OA.