Ping-Huei Tsai1, Cheng-Chieh Cheng1,
Ming-Huang Lin2, Chien-Yuan Lin2, Herng-Sheng Lee3,
Hsiao-Wen Chung1, Guo-Shu Huang4
1Graduate Institute of
Biomedical Electronics & Bioinformatics, National Taiwan University,
Taipei, Taiwan; 2Functional & Micro-Magnetic Resonance Imaging
Center, Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan; 3Department
of Pathology, Tri-Service General Hospital, National Defense Medical Center,
Taipei, Taiwan; 4Department of Radiology, Tri-Service General
Hospital, National Defense Medical Center, Taipei, Taiwan
Osteoarthritis (OA) is a disease related to the degeneration of knee cartilage and pathological changes of subchondral bone, which can lead to inflammation and pain. Several studies have demonstrated the importance of early detection of OA using quantitative measurements of MR T2 values of knee cartilage. In addition, perfusion change of bone would result in bone remodeling and cartilage degeneration. Therefore, the purpose of this study is using DCE-MRI to measure bone perfusion of rat patellofemoral joint with experimental OA. Our preliminary finding indicated the feasibility of using DCE-MRI to investigate bone perfusion during the progression of OA, which may contribute to early detection of OA.