Heng Ma1, Lan Ge2, Jing An3, David Chen2, Lixin Jin4, Xiaoming Bi5, Renate Jerecic4, Kuncheng Li1, Debiao Li2,6
1Xuanwu Hospital, Capital Medical University, Beijing, China, People's Republic of; 2Northwestern University; 3Siemens Healthcare, MR Collaboration NE Asia, Siemens Mindit Magnetic Resonance; 4Siemens Healthcare, MR Collaboration NE Asia, Siemens Limited China; 5Siemens Healthcare, Cardiovascular MR R&D, USA; 6Cedars-Sinai Medical Center and UCLA
Conventional myocardial perfusion MRI is limited by the low spatial coverage (3 to 4 slices), temporal and spatial resolution, signal-to-noise ratio, and cardiac motion-related image artifacts. A sliding-window conjugate-gradient HYPR (SW-CG-HYPR) technique allows increased spatial coverage (whole left ventricular coverage), resolution, signal-to-noise ratio and reduced motion artifacts. This work shows that myocardial adenosine stress perfusion MRI with SW-CG-HYPR is feasible and robust in a clinical population. Compared with conventional IR-Turbo-FLASH perfusion MRI, perfusion imaging with SW-CG-HYPR allows whole left ventricular coverage and has higher diagnostic accuracy in patients with suspected CAD.