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Abstract #1348

Improved Clinical Performance of a New Myocardial Adenosine Stress Perfusion Technique with SW-CG-HYPR at 3.0T: A Comparison to Conventional IR-Turbo-FLASH Perfusion MRI & X-Ray Angiography in Patients with Suspected Coronary Artery Disease

Heng Ma1, Lan Ge2, Jing An3, David Chen2, Lixin Jin4, Xiaoming Bi5, Renate Jerecic4, Kuncheng Li1, Debiao Li2,6

1Xuanwu Hospital, Capital Medical University, Beijing, China, People's Republic of; 2Northwestern University; 3Siemens Healthcare, MR Collaboration NE Asia, Siemens Mindit Magnetic Resonance; 4Siemens Healthcare, MR Collaboration NE Asia, Siemens Limited China; 5Siemens Healthcare, Cardiovascular MR R&D, USA; 6Cedars-Sinai Medical Center and UCLA

Conventional myocardial perfusion MRI is limited by the low spatial coverage (3 to 4 slices), temporal and spatial resolution, signal-to-noise ratio, and cardiac motion-related image artifacts. A sliding-window conjugate-gradient HYPR (SW-CG-HYPR) technique allows increased spatial coverage (whole left ventricular coverage), resolution, signal-to-noise ratio and reduced motion artifacts. This work shows that myocardial adenosine stress perfusion MRI with SW-CG-HYPR is feasible and robust in a clinical population. Compared with conventional IR-Turbo-FLASH perfusion MRI, perfusion imaging with SW-CG-HYPR allows whole left ventricular coverage and has higher diagnostic accuracy in patients with suspected CAD.