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Abstract #1366

High-Resolution Localization of Fibrosis in a Mouse Model of Viral Chronic Myocarditis using T2* Weighted MRI

Xavier Helluy1, Martina Sauter2, Yu-Xiang Ye3, Roland Jahns3, Ali Yilmaz4, Karin Klingel2, Karl-Heinz Hiller1, Peter M. Jakob1

1Magnetic Resonance Bavaria, Wuerzburg, Germany; 2Department of Molecular Pathology, University of Tuebingen, Germany; 3Department of Internal Medicine I, University Hospital of Wuerzburg, Germany; 4Division of Cardiology, Robert-Bosch-Krankenhaus, Stuttgart, Germany

Myocarditis which is the major cause of heart failure and sudden death in young adults is most often induced by viruses, importantly by coxsackieviruses. We report a novel application of T2* weighted MRI at 7T on the murine model of coxsackievirus B3 induced chronic myocarditis. T2* weigthed images show a negative contrast correlating with fibrosis distribution within the myocardium. The observed T2* contrast might be due to local field inhomogeneities induced by fibrotic tissue. Besides the value of characterizing the disease model in vivo, this finding could be a novel technique for diagnosing chronic myocarditis in humans or some other fibrosis-related diseases.