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Abstract #1367

T2 Mapping of the Mouse Heart using Segmented MLEV Supercycle Preparation

Bram F. Coolen1, Frank F. J. Simonis1, Rik P. M. Moonen1, Tessa Geelen1, Leonie E. M. Paulis1, Klaas Nicolay1, Gustav J. Strijkers1

1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

In this study, we present a novel method for robust T2 quantification in the mouse heart. The method makes use of an ECG-triggered non-selective T2 preparation consisting of MLEV weighted composite pulses, followed by a multi-slice k-space segmented acquisition. High quality images with different T2 weighting were obtained by segmenting the MLEV16 supercycle into different MLEV blocks, providing a broad TE range from 0.8 to 43.5 ms. Six healthy control mice were measured to assess reproducibility of the method and baseline values for myocardial T2.