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Abstract #1375

Quantitative Measurement of Myocardial T1 with a Modified Cine Inversion Recovery Pulse Sequence

Matteo Milanesi1,2, Andrea Barison3, Vincenzo Positano1, Luca Marinelli4, Pier Giorgio Masci1, Daniele De Marchi1, Christopher James Hardy4, Thomas K. Foo4, Luigi Landini1, Massimo Lombardi1

1MRI Laboratory, Fondazione G. Monasterio CNR Regione Toscana, Pisa, Tuscany, Italy; 2Magnet Technology Center, Agilent Technologies UK Ltd, Oxford, Oxfordshire, United Kingdom; 3Scuola Superiore Sant'Anna, Pisa, Italy; 4General Electric Global Research, Niskayuna, NY, United States

A modified version of the Cine-IR pulse sequence is herein introduced for T1 mapping of the myocardium. In the new sequence, data are acquired for a greater number of heart cycles following the inversion pulse than the original version used to do. This allows the pre-contrast myocardium to fully recover its longitudinal magnetization. The effective TR is adjusted according to the specific heart rate of the subject. In vivo results showed that the sequence is able to detect T1 differences between healthy and areas of myocardium positive to DE, both in pre and post contrast measurements