Hsiang Wei Ho1, Shang Yueh Tsai1, Yi Ru Lin2, Stefan Posse3,4, Fa Hsuan Lin5,6
1Electrical Engineering, Chang Gung University, Tao Yuan, Taiwan; 2Electronic Engineering, National Taiwan University of Science & Technology, Taipei, Taiwan; 3Neurology, University of New Mexico School of Medicine, Albuquerque, NM, United States; 4Electrical & Computer Engineering, University of New Mexico, Albuquerque, NM, United States; 5Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 66 MGH-HST Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States
Regional metabolite T2 relaxation times are necessary for absolute quantification of metabolite concentration. Here, 3-diemensional Proton-Echo-Planar-Spectroscopic-Imaging (PEPSI) is proposed to obtain T2 maps of three major cerebral metabolites in four consecutive slices in less than 20 minutes. Our results show consistent T2 values between subject and regional difference of NAA between WM and GM which in agreement with previous studies. The estimation of T2 values is stable according to the high Pearsons correlation coefficients between logarithmic MR signals and TE. In summary, PEPSI technique is a robust method to obtain fast maps of metabolite T2 values.