Meeting Banner
Abstract #1397

Ex Vivo Ischemic Kidney Damage 23Na Relaxometry

Christoffer Laustsen1,2, Steffen Ringaard1, Mads Damkjr3, Michael Pedersen1

1Klinisk Institut, The MR Research Centre, Aarhus University, Aarhus, Denmark; 2Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, Hvidovre, Denmark; 3Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark

Sodium is a pivotal metabolite in the equilibrium cell state, and is therefore an ideal candidate as a biomarker for macroscopic damage, which is directly linked to the cellular alterations in the sodium gradient across the cell membrane. We here show the use of a simple relaxometry method for gaining additional insight in ex vivo organs. We show that it is possible to differentiate the healthy kidney from the diseased by 23Na-multi-component relaxation analysis.