Improved Data Analysis for Two-Dimensional J-Resolved 1H-MRS: Application in Brain Tumors

Changho Choi¹, Sandeep Ganji¹, Elizabeth Maher²

Two-dimensional (2D) J-resolved spectroscopy may provide improved resolution for J-coupled resonances compared to conventional 1D data acquisitions. Single-voxel localized PRESS (point-resolved spectroscopy) data were acquired at 32 echo times from the tumor mass and contralateral normal-brain regions of three glimablastoma patients. The 2D NMR data were analyzed with spectral fitting (LCModel), using basis sets prepared with numerical calculation of model spectra that incorporated the actual parameters identical to those used in the data acquisition.