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Abstract #1409

Quantitative In Vivo Magnetic Resonance Spectroscopy using Synthetic Signal Injection

Kenneth I. Marro1, Donghoon Lee1, Eric G. Shankland1, C. Mark Mathis1, Cecil E. Hayes1, Martin J. Kushmerick1,2

1Radiology, University of Washington, Seattle, WA, United States; 2Physiology & Biophysics, University of Washington, Seattle, WA, United States

We have previously conducted in vitro measurements to demonstrate that conversion of MRS peaks to quantitative units of concentration can be efficiently achieved by using a second RF coil to inject a precalibrated, artificial reference signal into the data. In this work, we acquired 31P-MRS measurements from human tibialis anterior muscles and used pseudo-signal injection to determine PCr content. Our results demonstrate that pseudo-signal injection using inductive coupling provides a robust calibration factor that is immune to coil loading conditions and suitable for use in human measurements.