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Abstract #1408

Measuring Tissue PH Heterogeneity by 31P NMR Spectroscopy

Norbert W. Lutz1, Yann LeFur1, Patrick J. Cozzone1

1Dept. of Medicine La Timone, Marseille, France

Pathological processes are likely to induce variations in tissue pH. Thus, reliable measurement of intra and extracellullar pH (pHi, pHe) should be very useful for the characterization of tissue metabolism. 31P NMR-based methods exist for pHi (chemical shift, δ, of endogenous Pi), and for pHe (δ of exogenous APP). However, the consequences of pH heterogeneity within a measured tissue volume have not been considered in these pH calculations. We suggest here three 31P NMR-based pH calculation methods that take into account the characteristics of the pH distribution under consideration.