Abstract #1407

Cross-Validation of PRESS, MEGA-PRESS Editing & 2D JPRESS for Neurotransmitter & Antioxidant Detection at 3T using the ERETIC Reference Standard

Mariska Petra Luttje¹, Michael Wyss^1,2, Niklaus Zlch^1,2, Alexander Fuchs¹, Richard A. E. Edden^3,4, Susanne Heinzer⁵, Peter Bsiger¹, Anke Henning¹

¹Institute for Biomedical Engineering, University & ETH Zurich, Zurich, Switzerland; ²Contributed equally; ³Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States; ⁴F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; ⁵Philips AG, Zurich, Switzerland

SV PRESS, MEGA-PRESS and localized 2D JPRESS are compared to investigate their ability of quantifying GABA, Glu, Gln and GSH accurately. ERETIC has been applied as a reliable reference. Next to this, for all sequences the metabolite ratios with the internal water reference were calculated. JPRESS shows to be the best method for simultaneous quantification of the selected metabolites, while MEGA-PRESS GABA-editing proofs to be a faster and reliable method for studies that target mainly GABA. The metabolite/ERETIC ratio shows to be a more stable and hence reliable quantification method compared to the metabolite/water reference ratio for all tested sequences.