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Abstract #1442

In Vivo L-COSY MRS of Healthy Brain & Glioblastoma

Saadallah Ramadan1, Ovidiu C. Andronesi2, Peter Stanwell1, Alexander Lin1, Gregory A. Sorensen2, Carolyn Mountford1

1Radiology, Brigham & Women's Hospital, Boston, MA, United States; 2Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States

Acquisition and post processing parameters have been developed to allow, at 3T with a 32 channel head coil, an L-COSY to be acquired from the brain in 11 minutes. Cross peak assignments and relative ratios of metabolites in the healthy brain were recorded and statistically significant differences were recorded between healthy brain and glioblastoma. Good spectral resolution of the in vivo L-COSY allowed comparison with COSY from cultured cell lines.