Define Impact of Fasting on Human Brain Acid-Base Homeostasis using Natural Abundance 13C & 31P MRS

Napapon Sailasuta¹, Kent C. Harris¹, Thao Tran¹, Brian D. Ross¹

Natural abundance 13C MRS and proton decoupled 31P MRS were utilized to explore the impact of fasting on Intracerebral pH and acid-base homeostasis. There were no findings of altered pH when a significant reduction of HCO3 was found. This unexpected finding suggests unknown factors may be at play and relevant for outcome predictions in bicarbonate replacement therapy.