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Abstract #1446

Define Impact of Fasting on Human Brain Acid-Base Homeostasis using Natural Abundance 13C & 31P MRS

Napapon Sailasuta1, Kent C. Harris1, Thao Tran1, Brian D. Ross1

1Magnetic Resonance Spectroscopy Unit, Huntington Medical Research Institute, Pasadena, CA, United States

Natural abundance 13C MRS and proton decoupled 31P MRS were utilized to explore the impact of fasting on Intracerebral pH and acid-base homeostasis. There were no findings of altered pH when a significant reduction of HCO3 was found. This unexpected finding suggests unknown factors may be at play and relevant for outcome predictions in bicarbonate replacement therapy.