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Abstract #1476

MR Elastography of Mice in Experimental Autoimmune Encephalitis

Kerstin Riek1, Isabell Hamann2, Jason Millwald, Caspar Pfueller, Sebastian Hirsch1, Dieter Klatt, Jrgen Braun3, Carmen Infante-Duarte, Ingolf Sack1

1Department of Radiology, Charit University Medicine, Berlin, Germany; 2Cecilie-Vogt-Klinik fr Neurologie, Charit University Medicine; 3Institute of Medical Informatics, Charit University Medicine, Berlin, Germany

In multiple sclerosis (MS), diffuse brain parenchymal damage exceeding focal inflammation is increasingly recognized as a major cause of clinical disability. Experimental Autoimmune Encephalitis (EAE) is an animal model of MS that enables researchers to study neuronal tissue affected by chronic inflammatory. In this study, cerebral MRE of mice is used to study the relationship between brain viscoelasticity and degree of tissue degradation during EAE. Both symptomatic and asymptomatic EAE mice presented with a significant decrease in the storage modulus with age (p<0.05). In contrast there was no correlation between examination time and complex modulus in healthy controls.