Patrick Michael Heiler1, Saema Ansar2, Saskia Grudzenski2, Friedrich Wetterling1, Simon Konstandin1, Stephen Meairs2, Marc Fatar2, Lothar Rudi Schad1
1Computer Assisted Clinical
The paramagnetic lanthanide chemical shift agent TmDOTP5- is used in chemical shift imaging experiments and the technique is applied to an animal model of stroke model. It could be shown that TmDOTP5- induces a large hyperfine shift crossing neither the cell membrane nor the blood brain barrier. In ischemia, induced by occlusion of the MCA, TmDOTP5- shifts parts of the total sodium signal which indicates a disruption of the blood brain barrier.