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Abstract #1499

Intracellular Lithium by 7Li MRS: Effect of Total Li Concentration in Brain

Richard A. Komoroski1, Diana M. Lindquist2, John M. Pearce1

1Center for Imaging Research, University of Cincinnati, Cincinnati, OH, United States; 2Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

Intracellular lithium in brain in vivo can be estimated from the biexponential T2 behavior of the localized 7Li MRS signal. We report biexponential 7Li T2 relaxation studies in rat brain at 7 T with isotopically enriched 7LiCl to determine the compartmental distribution of Li as a function of brain Li concentration and to assess reproducibility and performance of a simple linear approximation to estimate intracellular Li from monoexponential T2 decay.