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Abstract #1500

Measurement of CMRO2 Changes by Somatosensory Stimulation in Rat using Oxygen-17 at 16.4 T

Hannes Michel Wiesner1, Rolf Pohmann1, David Zsolt Balla1, Wei Chen2, Kmil Ugurbil2, Kamil Uludag3

1High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tbingen, Germany; 2Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 3MBIC, Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands

Cerebral metabolic rate of oxygen (CMRO2) is a key indicator of brain function. We measured oxygen consumption non-invasively by imaging mitochondrial turn-over rate into H217O using inhalations of enriched 17O2 gas combined with 1H-BOLD methods in the same animal and session. We present estimated CMRO2 changes in the rat somatosensory cortex, which are based on chemical shift imaging (CSI) acquisitions colocalized with 1H-BOLD fMRI acquired at a field strength of 16.4 T. The dependence of ╬┤CMRO2 and BOLD-signal on the baseline physiology and stimulation parameters are discussed.