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Abstract #1545

Relationship between fMRI Signals in the Resting-State (R-fMRI) & Task (T-fMRI)

Sridhar Kannurpatti1, Bart Rypma2, Bharat Biswal1

1Radiology, UMDNJ-New Jersey Medical School, Newark, NJ, United States; 2School of Behavioral & Brain Sciences, University of Texas at Dallas, Dallas, TX, United States

We test the hypothesis that functional Magnetic Resonance Imaging (fMRI) blood oxygenation (BOLD) activity generated during the resting state (R-fMRI) and task-induced states (T-fMRI)originate from a common system. In other words, the activity is equivalent and independent of whether the subject performs a task or remains at rest in the MRI scanner. Using healthy human subjects for the study, we obtained linear relationships between resting signal and task-induced signal amplitudes (defined as the R-T relationship) on a voxel-wise basis and across subjects. Such a result reflects the resting- and task-induced BOLD-fMRI responses to arise from a common system.