Abstract #1608

On Connectivity Within the Default Mode Network: An ICA & Tractography Approach

Erik van Oort¹, David Norris¹

¹MR Techniques in Brain Function, Radboud University Nijmegen, Donders Institute, Nijmegen, Gelderland, Netherlands

This abstract describes detailed connectivity within the DMN. High quality rs-fMRI (35 minutes) and DWI (256 directions) data of 47 healthy subjects was acquired at 3T. The rs-fMRI data was examined using ICA methods on single subject level. The DMN was extracted using a group-ICA. Its regions were examined for local connectivity using sub-regions from the single-subject ICA using a partial correlation analysis. This analysis found nodes of connectivity in the PCC region of the DMN. The locations of these nodes show a good correspondence to the fiber tracking results.