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Abstract #1608

On Connectivity Within the Default Mode Network: An ICA & Tractography Approach

Erik van Oort1, David Norris1

1MR Techniques in Brain Function, Radboud University Nijmegen, Donders Institute, Nijmegen, Gelderland, Netherlands

This abstract describes detailed connectivity within the DMN. High quality rs-fMRI (35 minutes) and DWI (256 directions) data of 47 healthy subjects was acquired at 3T. The rs-fMRI data was examined using ICA methods on single subject level. The DMN was extracted using a group-ICA. Its regions were examined for local connectivity using sub-regions from the single-subject ICA using a partial correlation analysis. This analysis found nodes of connectivity in the PCC region of the DMN. The locations of these nodes show a good correspondence to the fiber tracking results.