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Abstract #1609

Dynamic Functional Connectivity Measures using FcMRI

Thomas W. Allan1, Matthew J. Brookes1, Susan T. Francis1, Penny A. Gowland1

1SPMMRM, University of Nottingham, Nottingham, United Kingdom

Electrophysiological measurements of functional connectivity (fc) have shown marked changes in fc over the time scale of typical resting state fcMRI recordings. Here we investigate whether these dynamic changes are observable in fcMRI. We 1) describe a technique to derive the statistical significance of fc maps constructed using varying length time windows; 2) measure dynamic changes in motor and default mode network connectivity showing a significant change in fc over time; 3) confirm that networks are active on both a short (20s) and long (300s) time scale.