Abstract #1644

Quantitative Evaluation of the Dynamic BOLD & CBF Responses to Breath Hold in Different Brain Territories

Wen-Cheng Chu¹, Yuan-Yu Hsu², Kun-Eng Lim², Ho-Ling Liu^1,3

¹Department of Medical Imaging & Radiological Sciences, Chang Gung University, Taoyuan County, Taiwan; ²Buddhist Tzu Chi General Hospital, Taipei County, Taiwan; ³Division of Medical Imaging & Intervention, Chang Gung Memorial Hospital, Taoyuan County, Taiwan

Blood oxygen level-dependent (BOLD) signal reflects a complex combination of cerebral blood function (CBF), cerebral blood volume (CBV), and oxygen consumption changes. Therefore, this study aimed to quantitatively evaluate the dynamics of CBF changes in the territories supplied by anterior cerebral artery, middle cerebral artery, and posterior cerebral artery obtained from the arterial spin labeling (ASL) experiment during breath-holding tasks. The averaged signal time courses were fitted using gamma-variate function, including three quantified parameters, such as onset time, FWHM, and maximum signal change. Here, this study demonstrated substantial differences between the BOLD and ASL responses to the breath-holding tasks.