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Abstract #1654

Ultra-Short Echo Time 19F/1H Imaging of Gadolinium-Free Perfluoro-Carbon Nanoparticles: A Robust Method for in Vivo Angiogenesis Imaging

Jochen Keupp1, Anne H. Schmieder2, Todd A. Williams2, J. S. Allen2, Samuel A. Wickline2, Gregory M. Lanza2, Shelton D. Caruthers2

1Philips Research Europe, Hamburg, Germany; 2C-TRAIN, Washington University School of Medicine, St. Louis, United States

Molecular imaging of integrin-targeted theranostic nanoparticles (NP) may offer profound impact on anti-angiogenic therapy. Previously, the value of ανβ3-targeted nanoparticles (NP) with large payloads of Gd has been shown. This work presents a novel 19F pulse sequence to image clinically-relevant perfluoro-octyl-bromide (PFOB) NP without Gd. Using 19F/1H radial 3D balanced UTE-SSFP sequence, angiogenesis is imaged in a rabbit Vx2 cancer model comparing ανβ3-targeted PFOB-NP with and without Gd. The new sequence is shown to allow robust, sensitive in vivo visualization of cancer-related neovasculature despite the complex resonant peak structure and the extended T1-relaxation time of Gd-free NP.