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Abstract #1707

Cellular MRI for Mapping Proliferation During Tumour Development

Lisa Michelle Gazdzinski1, Brian J. Nieman1

1Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada

Although tumours are comprised of a diverse population of cells, evaluation of tumour progression and treatment response most often consists of simple volume measurements, which cannot account for the heterogeneity in the cell population or in the corresponding tumour growth. We show that iron oxide labelling of tumour cells can be used to spatially map proliferative activity within a developing mouse glioma tumour. These methods represent a new role for cellular imaging techniques in cancer research and provide a platform for more detailed preclinical evaluation of novel cancer therapies.