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Abstract #1776

High-Resolution MRI of SPIO-Labeled Yttrium Microsphere Biodistribution in the Rodent Liver at 7T

Weiguo Li1, Zhuoli Zhang1, Daniel Procissi1, Andrew Gordon1, Jodi Nicolai1, Reed Omary1, Andrew Larson1

1Department of Radiology, Northwestern University, Chicago, IL, United States

Radioembolization with Yttrium-90 (90Y) microspheres is a relatively new form of intra-arterial therapy for Hepatocellular carcinoma. However, visualization and quantification of 90Y microsphere biodistribution using conventional radiologic modalities is challenging. Whereas labeling 90Y microspheres with SPIOs offers the potential to use MRI to visualize in vivo biodistribution, optimization of the amount of SPIO included within these microspheres may be critical. In this study, we have demonstrated the potential to optimize SPIO content for future studies intended to quantify microsphere concentrations in vivo; we found that spheres with relatively low SPIO contents will be ideal candidates for future study.