Electro-Nanotherapy Enhanced Delivery of Superparamagnetic Iron Oxide Nanoparticles in Liver Tumors: A Novel Means of Locoregional Drug Delivery

Samdeep Mouli¹, Noam Belkind¹, Weiguo Li¹, Jason Sandberg¹, David Magill¹, Rachel Klein¹, Daniel Procissi¹, Jodi Nicolai¹, Yang Guo¹, Andrew Larson¹, Reed Omary¹

We describe a novel locoregional technique, termed electro-nanotherapy, to increase the intra-tumoral uptake of dual imaging and therapeutic nanoparticles through tissue electroporation. Our results demonstrate the procedure results in a 6 fold increase in liver tumor nanoparticle uptake over conventional systemic delivery. Furthermore, using high resolution MRI T2 and T2* maps, we are able to assess the real-time biodistribution of these nanoparticles non invasively.