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Abstract #1777

Electro-Nanotherapy Enhanced Delivery of Superparamagnetic Iron Oxide Nanoparticles in Liver Tumors: A Novel Means of Locoregional Drug Delivery

Samdeep Mouli1, Noam Belkind1, Weiguo Li1, Jason Sandberg1, David Magill1, Rachel Klein1, Daniel Procissi1, Jodi Nicolai1, Yang Guo1, Andrew Larson1, Reed Omary1

1Radiology, Northwestern University, Chicago, IL, United States

We describe a novel locoregional technique, termed electro-nanotherapy, to increase the intra-tumoral uptake of dual imaging and therapeutic nanoparticles through tissue electroporation. Our results demonstrate the procedure results in a 6 fold increase in liver tumor nanoparticle uptake over conventional systemic delivery. Furthermore, using high resolution MRI T2 and T2* maps, we are able to assess the real-time biodistribution of these nanoparticles non invasively.