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Abstract #1821

High Throughput Microimaging of Mouse Brain & Embryo

Jun Dazai1, Michael Wong1, Christine Lalibert1, R. Mark Henkelman1

1Mouse Imaging Centre, the Hospital for Sick Children, Toronto, Ontario, Canada

Anatomical abnormalities, especially in neuroanatomy, are important indicators of human disease and their respective mouse models. Using magnetic resonance imaging (MRI) and subsequent image analysis, minute abnormalities in the mouse brain and embryos can be detected. Using a custom-built 16-coil solenoid array, 16 mouse brains were imaged concurrently to produce high-resolution, ex vivo 3D datasets with an effective throughput of less than 45 minutes per sample.