Yong Wang1, Qing Wang2, Peng Sun1, Fang-Cheng Yeh3, Wen-Yih Isaac Tseng4,5, Sheng-Kwei Song6
1Radiology, Washington University, Saint Louis, MO, United States; 2Mechanical Engineering & Material Sciences, Washington University, Saint Louis, MO, United States; 3Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States; 4Nuclear Engineering, National Taiwan University Medical College; 5Center for Optoelectronic Biomedicine; 6Radiology, Washington University in St. Louis, Saint Louis, MO, United States
Diffusion tensor imaging (DTI) fails dealing with crossing fiber and partial volume effect from surrounding environments (CSF, infiltrating cell, edema). To address the limitation of DTI, a multi-tensor based approach, diffusion basis spectrum imaging (DBSI), was proposed to accurately quantify multiple diffusion components in this study. Mouse trigeminal nerves were fixed and examined with and without gel embedding as the realistic phantom for the evaluation of DBSI. The preliminary findings suggest that DBSI has the potential to correctly determine the angle of crossing fibers as well as the diffusion properties of individual crossing fiber with gel mimicking vasogenic edema.