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Abstract #2033

Novel Artificial Phantom for Studies of Anisotropic Diffusion in the Model Brain Tissue

Ezequiel Farrher1, Joachim Kaffanke1, Tony Stoecker1, Farida Grinberg1, N. Jon Shah1,2

1Institute of Neuroscience & Medicine - 4, Forschungszentrum Juelich GmbH, 52425 Juelich, Germany; 2Department of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, 52074 Aachen, Germany

Diffusion-weighted MRI provides access to fibre pathways and structural characteristics in fibrous tissues such as white matter in the brain. Various factors such as restrictions, anisotropy, and compartmentalization imposed by the cellular microstructure cause a complexity of diffusion behaviour of water in the brain tissue. Therefore, it is important to develop artificial model systems with a reduced complexity in order to enable a better understanding of the relation between the experiments and the microstructure. In this work, we present a novel design for diffusion phantoms made of polyethylene fibres that exhibit sufficiently high anisotropy and a variation of fibre density within the same sample.