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Abstract #2051

Early Time Point Perfusion Imaging: Estimating Tissue Transit Time Directly from the Data Time Course

Kenneth K. Kwong1, Ona Wu1, Suk-Tak Chan1, Koen Nelissen1, David A. Chesler1

1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States

In MR perfusion analysis, the tissue mean transit time τ is normally estimated indirectly by using the ratio of regional cerebral blood volume (rCBV) and regional cerebral blood flow (rCBF). We propose two different methods to estimate τ directly using signals from the tissue contrast agent bolus concentration time course.