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Abstract #2060

Quantitative Perfusion & Permeability Analysis of Animal Brain using Dual Echo DCE-MRI

Yanming Yu1, Quan Jiang2, Haoyu Wang3, Shanglian Bao3, E. Mark Haacke4, Jiani Hu4

1Logging Technique Research Iinstitute, great wall drilling company, China National Petroleum Corporat, Beijing, China, People's Republic of; 2Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI, United States; 3Beijing Key Lab of Medical Physics & Engineering, Peking University, Beijing, China, People's Republic of; 4Department of Radiology, Wayne State University, Detroit, MI, United States

The purpose of this project is to investigate the effect of T2* on permeability and effect of T1 on perfusion using a new pharmacokinetic model with simultaneously acquired T1 and T2* DCE-MRI data. The preliminary results demonstrate that 1) T2* has great effects on the estimation of permeability parameters; 2) T1 has great effects on the estimation of perfusion parameters; 3) both the T1 and T2* effects are much greater in tumors when compared to healthy brain tissue. In conclusion, simultaneously acquired T1- and T2*-weighted DCE-MRI data can be used to improve the estimation accuracy of permeability and perfusion parameters.