Abstract #2060

Quantitative Perfusion & Permeability Analysis of Animal Brain using Dual Echo DCE-MRI

Yanming Yu¹, Quan Jiang², Haoyu Wang³, Shanglian Bao³, E. Mark Haacke⁴, Jiani Hu⁴

¹Logging Technique Research Iinstitute, great wall drilling company, China National Petroleum Corporat, Beijing, China, People's Republic of; ²Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI, United States; ³Beijing Key Lab of Medical Physics & Engineering, Peking University, Beijing, China, People's Republic of; ⁴Department of Radiology, Wayne State University, Detroit, MI, United States

The purpose of this project is to investigate the effect of T2^* on permeability and effect of T1 on perfusion using a new pharmacokinetic model with simultaneously acquired T1 and T2^* DCE-MRI data. The preliminary results demonstrate that 1) T2^* has great effects on the estimation of permeability parameters; 2) T1 has great effects on the estimation of perfusion parameters; 3) both the T1 and T2^* effects are much greater in tumors when compared to healthy brain tissue. In conclusion, simultaneously acquired T1- and T2^*-weighted DCE-MRI data can be used to improve the estimation accuracy of permeability and perfusion parameters.