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Abstract #2061

Modeling of Look-Locker Estimates of the Magnetic Resonance Imaging Estimate of Longitudinal Relaxation Rate in Tissue After Contrast Administration

Ramesh Paudyal1, Hassan Bagher-Ebadian1, Robert A. Knight1,2, Tavarekere N. Nagaraja3, Joseph D. Fenstermacher3, James R. Ewing1,2

1Neurology, Henry Ford Hospital, Detroit, MI, United States; 2Physcis, Oakland University, Rochester, MI, United States; 3Anesthesiology, Henry Ford Hospital, Detroit, MI, United States

In this study, we evaluate the effects of equilibrium intercompartmental water exchange kinetics in a monoexponential estimate of tissue water protons relaxation rate R1 using an experimentally measured plasma concentration vs. time, an arterial input function (AIF), of a paramagnetic contrast agent like Gd-DTPA via a Look-Locker measurement in a three site two exchange [3S2X] model. The observable change in R1 was used in a Patlak graphical plot to asses the influence of protons of water exchange on the measured cerebrovascular parameters.