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Abstract #2133

Diffusion Weighted Magnetic Resonance Spectroscopy in Different Stages of Human Cerebral Ischemia

Dandan Zheng1, Zhenghua Liu2, Xiaoying Wang1,2, Jue Zhang1,3, Jing Fang1,3

1Academy for Advanced Interdisciplinary Studies, Peking University, BEIJING, China, People's Republic of; 2Dept. of Radiology, Peking University First Hospital, BEIJING, China, People's Republic of; 3College of Engineering, Peking University, BEIJING, China, People's Republic of

Cerebral ischemia is a principal cause of death and severe disability globally. Previous studies showed that DW-MRS offers excellent tools to specifically measure the intracellular response to cerebral injury. The purpose of this study is using DW-MRS to investigate the pathological related changes in apparent diffusion coefficient (ADC) values of metabolites in cerebral ischemia in vivo. The results demonstrate that the ADC values of the cerebral metabolites significantly decrease and increase in the acute and subacute stages of ischemia respectively, compared to the age matched healthy controls.