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Abstract #2134

Non-Invasive Method to Image Cerebral Blood Volume Increases in Acute Ischemic Stroke Patients

Alan J. Huang1,2, Li An3, Jun Hua1, Manus Donahue4, Steven Warach3, Peter van Zijl1

1FM Kirby Research Center, Johns Hopkins University, BALTIMORE, MD, United States; 2Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; 3National Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD, United States; 4Department of Radiology, Vanderbilt University, Nashville, TN, United States

Acute stroke patients require a rapid and individualized diagnosis to evaluate whether thrombolysis treatment is necessary. Vascular Space Occupancy (VASO) MRI is a non-invasive technique that allows for imaging of increased microvascular blood volume, a marker for tissue at risk of infarction. An initial evaluation of five patients imaged within 7 hrs post-ischemic onset shows that VASO can be used to assess CBV increases in white matter. Our results show that VASO can potentially spatially localize the ischemic penumbra better than current perfusion weighted imaging.