Meeting Banner
Abstract #2137

Resting State fMRI of Acute Focal Ischemic Rat Brain

Yen-Yu Ian Shih1, Hsiao-Ying Wey1, Fang Du1, Shiliang Huang1, Qiang Shen1, Kameel M. Karkar1, Timothy Q. Duong1

1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

This study applied rsfMRI to probe acute focal ischemia in rat. During 15 mins acquisition, there were typically a few (3) epochs of spontaneous BOLD waves. Each wave showed 12% BOLD increases (at 7 T) and the duration was on the order of 2-3 mins. The BOLD wave started in the cortex, spread downward, grew in size, and ended in the striatum. These characteristic waves are likely associated with peri-infarct spreading depolarization. This method provides unique and clinically relevant information to probe tissue at risk, which may have long-term clinical applications.