Yen-Yu Ian Shih1, Hsiao-Ying Wey1, Fang Du1, Shiliang Huang1, Qiang Shen1, Kameel M. Karkar1, Timothy Q. Duong1
Institute, University of
This study applied rsfMRI to probe acute focal ischemia in rat. During 15 mins acquisition, there were typically a few (3) epochs of spontaneous BOLD waves. Each wave showed 12% BOLD increases (at 7 T) and the duration was on the order of 2-3 mins. The BOLD wave started in the cortex, spread downward, grew in size, and ended in the striatum. These characteristic waves are likely associated with peri-infarct spreading depolarization. This method provides unique and clinically relevant information to probe tissue at risk, which may have long-term clinical applications.