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Abstract #2138

MRI-Based Measurement of Longitudinal Contralesional White Matter Volume Changes After Unilateral Stroke in Rat Brain

Willem M. Otte1,2, Kajo van Der Marel2, Maurits P. A. van Meer2, Kees P. J. Braun1, Rick M. Dijkhuizen2

1Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands; 2Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands

The spatiotemporal dynamics of white matter changes in stroke recovery are poorly characterized. We assessed the contralesional white matter volume serially in a unilateral stroke model in rats using multimodal MRI and supervised segmentation. We found substantial changes in contralesional white matter volume development after stroke. These results indicate the potential role of contralateral white matter structure in stroke recovery and the feasibility of supervised segmentation algorithms in characterizing these volumetric white matter changes.