1Team 5 - INSERM U836 / Joseph Fourier University, Grenoble Institute of Neurosciences (GIN), Grenoble, France; 2Cell & Tissue Therapy Unit, Grenoble University Hospital, Grenoble, France; 3Intensive Care Unit, Grenoble University Hospital, Grenoble, France; 4Stroke Unit, Department of Neurology, Grenoble University Hospital, Grenoble, France
In a rat model of stroke, hemodynamic and oxygenation changes during acute cerebral ischemia were studied using a multimodal quantitative BOLD approach (Apparent Diffusion Coefficient (ADC), Blood Volume fraction (BVf) and local Oxygen Saturation (lSO2). We identified the potential ischemic core as the region with low ADC and BVf values and a severe hypoxia (lSO2< 35%) discrepant with tissue survival. The hypoxia ROI was smaller than the decreased ADC one. ADC and BVf values were similar both into the decreased ADC ROI and into the hypoxia ROI. Our method could become a way to investigate patients eligible for thrombolysis.